Scrutiny procedure requires prompt defect notification and cure or invalidation, with fee forfeiture and potential reuse of contents. Regulation 16 requires the Secretary to scrutinize each information, reference or miscellaneous application and notify defects within short prescribed periods; recipients must cure defects within specified cure periods or the submission will be treated as invalid and fees forfeited, though the Commission may still use the submission's contents for inquiry and the cure period does not count toward the Commission's statutory opinion period.