<h1>Earthquake kills over 2,200, leaves tens of thousands homeless; UN appeals for $139M amid access and gender restrictions</h1> A major earthquake in eastern Afghanistan killed over 2,200 people, injured more than 3,600, destroyed thousands of homes and left tens of thousands homeless and exposed to imminent winter conditions; UN agencies are appealing for urgent funding, seeking roughly USD 139 million to aid hundreds of thousands over four months while one agency separately seeks support for about 134,000 people. Access to remote mountain villages is difficult, slowing delivery of tents and supplies; aid has reached some 60,000 with food and 30,000 with water, but needs far outstrip resources. Restrictions imposed by the de facto authorities on women's participation in UN operations are impeding relief efforts.