<h1>Limb-preserving cancer surgery restores function after extensive bone and soft-tissue resection through coordinated multidisciplinary reconstruction.</h1> A multidisciplinary team conducted tumor and bone resection with lymph nodal clearance for advanced skin cancer, then reconstructed the defect using an autologous bone graft from the unaffected leg and a microvascular soft-tissue transfer from the back, followed by skin reconstruction to preserve limb function and restore structural stability.