Appendix 4E compliance requires full technical disclosure to prevent deferment of chemical advance authorisation applications. Non-submission of complete Appendix 4E is causing deferment of advance authorisation applications for chemicals filed on a self declaration basis. Applicants must provide step wise manufacturing processes, full chemical reactions with molecular and structural formulas and weights, stage wise molar yields, material balance, solvent requirement and recovery, by product/co product details, finished product purity and standard technical literature so Regional Authorities can forward complete dossiers to the Norms Committee for time bound processing.