<h1>CHANDO 4-Butylresorcinol (577) research shows targeted microRNA inhibition reduces melanin and brightens Asian skin with high tolerability.</h1> CHANDO identified that a specific microRNA drives UV-induced pigmentation by regulating MITF, TYR, and TYRP1, and reported that 4-Butylresorcinol (577) inhibits this microRNA's abnormal expression to reduce melanin overproduction; laboratory and clinical testing showed reductions in dark spots and sallowness with high tolerability, and 577 has been incorporated into CHANDO's Cellcrystal Whitening Radiance Series.