Single Window Simplification: streamlined ADC clearance for non-pharmaceutical and declared non-pharmaceutical-use consignments via integrated electronic declarations. The notice directs that items identified on the PGA Exemption Category (PEC) list as chemicals not drugs be declared in the Integrated Declaration to avoid ADC referral; allows electronic declarations that dual-use items are non-pharmaceutical grade and contain no API and that end-use is non-medicinal to normally prevent ADC referral; mandates risk-based sampling with ADC-drawn samples where required and forbids repeat sampling of the same tested batch; accepts digitally signed integrated declarations as substitute for hard-copy undertakings; and maps ICES locations to nearest ADCs for regulatory routing.